NOTE: Edited Article below. Emphasis added. To read the entire original article go to: Living for Two  

Living for Two
By Shari Roan, Los Angeles Times Staff Writer

If Aly Hartman could have placed herself in a protective bubble for the duration of her recent pregnancy, she would have done so.

The Marina del Rey woman, 28, cut out alcohol, sodas and caffeine... and began stocking up on organic fruits and vegetables. She ducked back into her car while pumping gas and, when driving, sped around vehicles emitting thick fumes. She avoided crowds and handshakes, bought all-natural cleaning products and stopped wearing perfumes and lotions.

The child-talent agent admits her safety measures may seem a bit extreme, but she may actually be a model for all pregnant women.

What women eat, touch and breathe during pregnancy now appears to be more important to their babies' health than anyone ever imagined. Mounting scientific evidence suggests that fetuses are surprisingly susceptible to outside influences, such as food, environmental chemicals and pollutants, infections, even stress.

Under this theory -- called fetal programming -- babies are born not just with traits dictated by their parents' genes, such as brown eyes and olive skin. They may be born with a tendency to develop asthma, diabetes or other illnesses based on what their mothers ate and were exposed to during pregnancy.

Already known were the obvious, and serious, risks posed by smoking, drinking and drug use. Now researchers are homing in on subtler changes in the fetal environment that can influence a child's health even into adulthood.

"Fetal life and early infancy are now recognized as periods of remarkable susceptibility to environmental hazards," says Dr. David Barker, a British researcher who is widely credited with recognizing the link between low birth weight and later cardiovascular disease. "The diets of mothers have massive long-term effects on their babies."

Once confined to experts in fetal health, fetal programming is now attracting scientists who study adult conditions, such as diabetes, heart disease, cancer, asthma, schizophrenia and infertility. By understanding the origins of susceptibility, they hope to understand how such diseases might be prevented, says Jerry Heindel, a biochemist and scientific program administrator at the National Institute of Environmental Health Sciences.

"People are realizing that maybe they've been looking at the wrong time frame for the role of environment and disease," says Heindel, who developed a program at the institute to study the fetal basis for disease.That's not to say that Heindel and other fetal-programming experts are suggesting pregnant women take every possible precaution for fear of dooming their children. Such research is in its infancy, and many questions and controversies remain, Heindel says. And he adds: Diseases are caused by a combination of genes and environment or by many factors that collude.

Still, many fetal-programming experts say reproductive-age men and women need to know that they probably have more control over their children's future health than they realize.

"You can't help but be a little bit scared of everything that could go wrong," says Hartman. "There are a lot of things outside of your control. But I was surprised to learn how much is in my control."

Evidence of susceptibility

History has delivered several sobering reminders that the human fetus is vulnerable to outside influences. Birth defects caused by medications such as thalidomide in the late 1950s and more recently the acne drug Accutane demonstrate that doses that have little effect on an adult can cause devastating changes in a fetus.

"The early teaching was that the placenta offered incredible protection against the fetus," says Dr. Philip Landrigan, chairman of the department of Community and Preventive Medicine at Mount Sinai School of Medicine in New York City. "Thalidomide was the first episode that made the medical profession and public realize that the placenta is not some sort of impervious barrier."

But the most jarring part of the fetal-programming hypothesis -- and the hardest to prove -- is that even seemingly harmless doses of ubiquitous substances at the wrong stage of development can produce deleterious effects.

"More recently we've recognized that you can still have these effects in the absence of disastrous damage," Landrigan says. "We've come to realize that if a pregnant woman eats a half-a-dozen cans of tuna fish at the wrong time of pregnancy, that might be harmful."

Contamination of fish with very high concentrations of methylmercury from industrial sources has caused clusters of severe birth defects in several places around the world. But more recent research, including three large epidemiological studies, suggests that even methylmercury concentrations commonly found in the United States can cause subtle changes in the fetus, such as lower IQ and decreased cognitive performance in childhood, Landrigan says.

And increasingly, scientists fear that fetuses and young children may be harmed by pesticides and pollutants that, at the same level, cause no measurable harm in adults. For example, some common pesticides are thought to be so-called endocrine disrupters, chemicals that change hormone function in utero and can affect reproductive organ development and function later in life.

Likewise, levels of air pollutants commonly found in many urban areas may cross the placenta of a pregnant woman and affect her fetus. More than a dozen studies worldwide have linked air pollution to low birth weight, stillbirth and intrauterine growth retardation. According to the World Health Organization, air pollution can impair lung function in the womb.

The implications of fetal programming are profound, Heindel says. Some preliminary research suggests that an environmental influence in pregnancy may not only affect the fetus but also future generations as well.

Scientists refer to such changes as epigenetics. During critical time periods of human development, the body alters gene expression (even though the DNA sequence itself is unchanged), which may lead to a predisposition to disease in the offspring.

"That means what your grandmother was exposed to could affect your health today," says Heindel. "That is what makes this so scary. The data is so scanty at this time that we don't know how strong that is. If it turns out to be true, it could be very important."

Mixed benefits

Not all exposures are bad. Research published last year in the Archives of Disease in Childhood, showed that pregnant women consuming supplements of omega-3 fatty acids were more likely to have babies with good hand-eye coordination and language comprehension.

But that finding highlights the dilemma pregnant women often face: Trying to eat healthy can sometimes increase the likelihood of toxic chemical exposures.

To use the fish research, some types of fish contain not just omega-3 fatty acids but high levels of mercury and other toxic chemicals. As a result, pregnant women are advised to eat no more than 12 ounces of seafood a week. And a study published online in April in the journal Thorax found that the children of women who ate lots of apples during pregnancy had less asthma later in life than did the children of women who ate few apples. Sounds good. But apples can also contain high levels of pesticides which, research shows, might be harmful to a developing fetus, acting as endocrine disrupters or causing neurological damage.

Advice isn't clear-cut

But advising pregnant women is difficult.

"Physicians always have to walk a delicate line between frightening people to death and, on the other hand, providing them with bland and meaningless reassurances," Landrigan says. "But we in the profession need to do a better job of getting this information out to the public. I think this [fetal-programming] message is not as widely appreciated as it should be."

He advises people to think about which chemicals to use and store in their homes and whether to buy organic foods and nontoxic products.

"This is all about empowering people with information," he says.

Good information isn't always easy to find, however. Lawmakers should make more of an effort to define which substances may harm a fetus, at what amounts and when, says Brenda Eskenazi, an epidemiologist at UC Berkeley and director of the Children's Center for Environmental Health. Most laws on toxic exposures are based on levels that could affect an adult -- not a child or developing fetus, who are thought to be even more vulnerable. To that end, a state law passed last year established a biomonitoring program that will assess the presence and concentration of designated chemicals in Californians by testing blood, urine and breast milk samples.

Scientists also need to find better ways to measure toxic exposures. In a notable study published last month in the journal Genome Biology, researchers found they could identify individual toxins at work in zebrafish embryos by reading the specific gene expression. The research offers a potential method of identifying the effects of toxins on developing vertebrate embryos to see if they are harmful and, if so, at which times in fetal development.

"A lot of our problem in this whole field is the ability to measure exposure," Eskenazi says. "Some laboratories are developing new and great ways of measuring chemical exposures. Many of these exposures are short-lived, and we may not be picking them up. But they can have long-term consequences."

Although many questions about fetal programming remain, enough is now known to alert consumers, says Eskenazi.

Hartman, who had a healthy baby girl late last month, agrees.

"Knowledge is power," she says. "The more you can know about having healthy babies, the better."

 

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"Homemade Cleaning Supplies" http://curezone.com/blogs/m.asp?f=309&i=87 

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